มัลติเพิล มัยอีโลมา

Key Facts

• Plasma cells multiply uncontrollably in bone marrow
• Dogs: classic bone marrow form; cats: often affects liver/spleen instead
• Complications: hypercalcemia, kidney disease, bone destruction, hyperviscosity syndrome, bleeding disorders
• Signs: weakness, lethargy, vomiting, bone pain, lameness, nosebleeds
• Diagnosis: elevated globulin on blood work, serum protein electrophoresis (monoclonal spike), bone marrow biopsy
• Moth-eaten bone appearance on X-rays; Bence-Jones proteins in urine
• Treatment: chemotherapy (melphalan + prednisone is standard); cure is rare
• Median survival dogs: 220-930 days with treatment; cats: 42-281 days
• Species: dogs and cats (rare)