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Mast Cell Tumor
Mast cell tumors are among the most common skin tumors in dogs and the second most common skin tumor in cats. They arise from mast cells, which are immune cells involved in allergic and inflammatory responses.
Key Facts
- Dogs: most common skin tumor; highly variable behavior from benign to aggressive
- Cats: second most common skin tumor; most feline cutaneous mast cell tumors are benign
- Predisposed dog breeds: Boxer, Boston Terrier, Labrador, Golden Retriever, Pug
- Diagnosis by fine-needle aspirate; grading by biopsy
- Treatment: wide surgical excision; radiation and chemotherapy for high-grade tumors
- Can release histamine causing GI ulcers; antihistamines often prescribed
- Species: dogs and cats